Efficacy of ondansetron in mitigating hemodynamic alterations caused by spinal anesthesia in segmental cesarean section

Abstract

Supine hypotension syndrome in pregnant women at term continues to be a challenge for the anesthesiologist since subarachnoid anesthesia (SA) triggers sympatholysis reflected in hypotension and bradycardia leading to fetal hypoxemia and maternal complications. Objective: The effectiveness of ondansetron in reducing the hemodynamic effects of anesthesia (SA) in patients undergoing segmental cesarean section was evaluated at “Dr. Rafael Calles Sierra” Hospital in Punto Fijo. Methodology: The research was comparative, prospective, cross-sectional, and was conducted in a population of 30 patients who met the inclusion criteria. They were separated into two groups, A (ondansetron) and B (0.9% solution), 5 minutes prior to the anesthetic technique, in order to evaluate the hemodynamic changes in the patients undergoing the study, as well as the use or not of vasopressors. Results: It was determined that in a total of 13 patients (43.3%) the use of vasopressors was not required, all belonging to group A, however, in a total of 17 patients (56.7%) the use of vasopressors was necessary, 2 (6.7%) from group A and 15 (50%) from group B, Conclusion: In the study patients there were hemodynamic changes in both groups, however, group B was the one that presented much more marked changes, given by hypotension, bradycardia, desaturation and complications, thus determining that there were statistically significant differences between the groups studied.